A Novel Multiple Marker Bioassay Utilizing HE4 and CA125 for the Prediction of Ovarian Cancer In Patients With a Pelvic Mass. In Gynecol Oncol, 2009, 112 (1):40-6.
Material and Methods . This prospective study included 302 patients admitted for surgical treatment due to adnexal tumors. The ROMA was calculated depending on CA125, HE4, and menopausal status. Results. A comparison of CA125, HE4, risk ovarian malignancy algorithm (ROMA), and risk malignancy index (RMI) for the classification of ovarian masses. Clinics. 2012;67(5):437-441.
June 2018; Current Problems in Cancer 43(2) DOI: 10.1016/j.currproblcancer.2018.06.001 ROMA index calculation. The ROMA index was calculated according to the levels of HE4 and CA-125. HE4 and CA-125 values were input to the ovarian cancer risk assessment soft-ware, followed by automatic calculation of the corresponding ROMA index. The premenopausal calculation formula of the ROMA index was: 12+2.38 x LN(HE4)+0.062 6 x LN(CA -125 The ROMA index combined serum CA125 HE4 and menopausal state with multiple parameters, which greatly improved the accuracy of single factor diagnosis of ovarian cancer. The preoperative assessment of the patient and the accurate judgment of the pelvic masses will be beneficial to the patient’s further treatment and even the prognosis. REVIEW Open Access Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review Vincent Dochez1*, Hélène Caillon2, Edouard Vaucel1, Jérôme Dimet3, Norbert Winer1 and Guillaume Ducarme4 Abstract Ovarian cancer is the 5th leading cause of death for women with cancer worldwide.
Serum levels of CA125 and HE4, and ROMA index were higher in patients with different types of malignant tumor than those in corresponding benign group. Serum HE4, serum CA125, and ROMA index had better performance in the diagnosis of postmenopausal ovarian cancer than that of premenopausal ovarian cancer. This online calculator tool is based on the ROMA slide rule, a tool to help approximate the risk of epithelial ovarian cancer using CA125 and HE4 test values.
21 Mar 2011 combination, within the risk of malignancy index (RMI) and the newly HE4 is superior to CA125 with or without RMI and ROMA indices.
Combinarea HE4 cu CA 125 a dus la creșterea sensibilității detectării în comparație cu folosirea doar a antigenului CA 125 (50.1 vs 24.6% la o specificitate de 95%) și cu utilizarea doar a marker-ului HE4 pentru stadiile II-IV de boala (86.6 vs 83.6%); asocierea nu a avut un impact asupra sensibilității în comparație cu HE4 izolat la pacientele în stadiul I sau atunci când s-au The combination of CA 125™ + HE4 tests from Fujirebio Diagnostics, Inc., helps ovarian cancer patients find the right doctor for the most optimal outcome. 19 Oct 2020 The sensitivity of the ROMA index was higher (P<0.01) with detection of HE4 and CA-125. In the ovarian cancer group, the areas under ROC 25 Oct 2019 ROMA: Risk of Ovarian Malignancy Index.
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2013-09-18 CA125 + HE4 Ovarian Biomarker Tool iPhone Application. Available on iTunes, the multi-lingual application, available in English, French and Italian (Chinese and German coming soon) features the ROMA calculator to generate a risk of ovarian malignancy.It also provides an overview of the ROMA results and how patients may be classified into low or high risk based on the Predictive Index.
Serum HE4, serum CA125, and ROMA index had better performance in the diagnosis of postmenopausal ovarian cancer than that of premenopausal ovarian cancer. HE4 and ROMA index which reference intervals are established according to the menopausal status have important clinical significance in the diagnosis of ovarian cancer. Regular detection of serum HE4, CA125, and ROMA index can help predict postoperative recurrence of ovarian cancer. The sensitivity of the ROMA index was higher (P<0.01) with detection of HE4 and CA-125.
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We recruited 159 women and the HE4 and CA125 were measured with an electrochemiluminescence immunoassay in the sera. We used the … HE4 + CA-125 rizikó becsléssel (ROMA-index) Élettani, kórélettani háttér. A petefészek rák az egyik leggyakoribb nőgyógyászati daganat.
In Gynecol Oncol, 2009, 112 (1):40-6. ROMA has a higher sensitivity and specificity in detecting stages I/II ovarian cancer than CA 125 alone 8 Determining HE4 and CA 125 independently can improve ovarian cancer monitoring Either HE4 or CA 125 levels can be elevated in patients during therapy monitoring and recurrence monitoring 9-11; At disease progression, some patients show an
Tumorski markeri HE4, CA125 i ROMA indeks mogu biti markeri za odvajanje malignih i benignih tumora jajnika u pre i postmenopauzi.
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The risk of malignancy index (RMI) is a well-established risk-stratification tool that HE4 and ROMA, like CA-125, have no role in screening for ovarian cancer.
Tumour Biol . 2014 Jun;35(6):6127–38.
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Cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) are biomarkers for ovarian cancer. Their specificity and sensitivity are often limited during pregnancy as a result of great fluctuations. The risk of ovarian malignancy algorithm (ROMA) score, which combines CA125, HE4, and menopausal status, may improve diagnostic performance.
CA 125, HE4, and ROMA exhibiting maximum Youden index were determined, respectively, as the optimal cutoffs, and sensitivity and specificity were evaluated by applying those cutoffs.